There is a launch of norepinephrine from your descending inhibitory bulbospinal neurons that binds to alpha-2-receptors during the dorsal horn to reduce afferent ache transmission and generate analgesia. Hence, medication like clonidine that focus on alpha-2 receptors can influence the transmission of discomfort. You could possibly explain to this https://paulinex940oeu4.tokka-blog.com/profile