Abstract Increased protein citrullination (PC) and dysregulated protein arginine deiminase (PAD) activity have been observed in several neurodegenerative diseases. PC is a posttranslational modification catalyzed by the PADs. PC converts peptidyl-arginine to peptidyl-citrulline. thereby reducing the positive charges and altering structure and function of proteins. https://www.roneverhart.com/Echo-Fix-EF-P2-Spring-Reverb-Pedal-p32083/