DNA ligases seal 5′-PO4 and 3′-OH polynucleotide ends via a few nucleotidyl transfer techniques involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are necessary guardians of genomic integrity, and ligase dysfunction underlies human genetic disease syndromes. Crystal structures of DNA ligases bound to nucleotide and nucleic acid substrates have illuminated https://kinkyw445idw0.blogsumer.com/profile